Vesicle Associated Membrane Protein 2 (VAMP2)
SYB2; VAMP-2; Synaptobrevin 2
VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. Mice lacking functional synaptobrevin2/VAMP2 gene cannot survive after birth, and have a dramatically reduced synaptic transmission, around 10% of control. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and complexin. It also forms a distinct complex with synaptophysin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Hu01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Hu01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Hu01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Hu01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Hu01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Mu01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Mu01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Mu01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Mu01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Mu01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Ra01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Ra01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Ra01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Ra01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Ra01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Ca01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Ca01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Ca01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Ca01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Ca01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Po01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Po01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Po01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Po01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Po01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Bo01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Bo01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Bo01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Bo01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Bo01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Rb01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Rb01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Rb01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Rb01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Rb01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR235Mo01 | Recombinant Vesicle Associated Membrane Protein 2 (VAMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR235Mo01 | Monoclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IP. |
| PAR235Mo01 | Polyclonal Antibody to Vesicle Associated Membrane Protein 2 (VAMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR235Mo01 | CLIA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | CLIA assay for Antigen Detection |
| ELR235Mo01 | ELISA Kit for Vesicle Associated Membrane Protein 2 (VAMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2."
J. Biol. Chem. 265:17267-17273(1990) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2."
Biochem. J. 317:945-954(1996) [PubMed] [Europe PMC] [Abstract]
"Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane."
EMBO J. 14:217-223(1995) [PubMed] [Europe PMC] [Abstract]
"Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution."
Nat. Struct. Biol. 7:687-692(2000) [PubMed] [Europe PMC] [Abstract]