Nuclear Factor I/X (NFIX)

NF1A; CTF; CCAAT-Binding Transcription Factor; TGGCA-binding protein

SPN	R171
HGNC	7788
MGI	97311
PubMed	20673863
RGD	69080
UniProt	Q14938
Wiki	NFIX

Nuclear factor I is a ubiquitous 47-kD dimeric DNA-binding protein whose recognition sequence, TGG(C/A)N(5)GCCAA, is found in the genomes of a number of DNA viruses. The same sequence occurs frequently in the human genome. The NFI protein stimulates initiation of adenovirus DNA replication in vitro and is capable of stimulating the transcription of genes in cooperation with other factors, such as the estrogen receptor (ESR). Santoro et al. (1988) gave a detailed analysis of NFI cDNAs isolated from the human, which, with similar analyses in other species, indicated that it is a member of a family of related proteins. Seisenberger et al. (1993) isolated 2 phages containing the second exon and flanking intron regions of the human gene for NFI/X, which has been designated NFIX.

Reference

"Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner."
Nucleic Acids Res. 22:3825-3833(1994) [PubMed] [Europe PMC] [Abstract]

"Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes."
J. Neurovirol. 2:87-100(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH."
Genomics 28:66-73(1995) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Distinct effects of allelic NFIX mutations on nonsense-mediated mRNA decay engender either a Sotos-like or a Marshall-Smith syndrome."
Am. J. Hum. Genet. 87:189-198(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features."
J. Hum. Genet. 57:207-211(2012) [PubMed] [Europe PMC] [Abstract]