Nuclear Transcription Factor Y Gamma (NFYC)

CBF-C; NFYg; CBFC; H1TF2A; HAP5; HSM; NF-YC; hCBF-C; CAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C; Transactivator HSM-1/2

SPN	R169
HGNC	7806
MGI	107901
PubMed	16287085
RGD	3173
UniProt	Q13952
Wiki	NFYC

Nuclear transcription factor Y subunit gamma is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes.

This gene product, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.

Reference

"Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox."
J. Biol. Chem. 271:28784-28791(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of human NF-YC."
Gene 193:119-125(1997) [PubMed] [Europe PMC] [Abstract]

"Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor."
Gene 197:161-163(1997) [PubMed] [Europe PMC] [Abstract]

"Cell cycle-dependent switch of up- and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y."
J. Biol. Chem. 274:24270-24279(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y."
J. Biol. Chem. 278:1336-1345(2003) [PubMed] [Europe PMC] [Abstract]

"Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination."
Cell 152:132-143(2013) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]