2',5'-Oligoadenylate Synthetase 3 (OAS3)

p100OAS

SPN	R146
HGNC	8088
MGI	2180850
PubMed	19056102
UniProt	Q9Y6K5
Wiki	OAS3

2'-5'-oligoadenylate synthetase 3 is an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.

The domains share 44 to 60% protein sequence similarity with each other and 42 to 60% sequence identity with the conserved domain of OAS1. The authors noted that OAS1, OAS2, and OAS3 contain 1, 2, and 3 conserved OAS domains or units, respectively. Northern blot analysis revealed that OAS3 is expressed as a 7-kb interferon-induced mRNA in HeLa cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Hu01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Hu01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Hu01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Hu01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Hu01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Mu01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Mu01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Mu01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Mu01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Mu01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Ra01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Ra01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Ra01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Ra01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Ra01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Ca01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Ca01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Ca01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Ca01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Ca01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Po01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Po01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Po01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Po01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Po01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Bo01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Bo01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Bo01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Bo01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Bo01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Rb01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Rb01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Rb01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Rb01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Rb01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR146Mo01	Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR146Mo01	Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IP.
Antibodies	PAR146Mo01	Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3)	WB; IHC; ICC; IF.
Assay Kits	CLR146Mo01	CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	CLIA assay for Antigen Detection
Assay Kits	ELR146Mo01	ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains."
J. Biol. Chem. 274:1557-1565(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of T cell-mediated recognition of pancreatic cancer cells."
Cancer Res. 61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the gene encoding the 100-kDa form of human 2', 5'oligoadenylate synthetase."
Genomics 70:232-240(2000) [PubMed] [Europe PMC] [Abstract]