Polymerase DNA Directed Delta 1 (POLd)

CDC2; POLD1; DNA polymerase subunit delta p125

SPN	R114
HGNC	9175
MGI	97741
PubMed	24501277
RGD	621839
UniProt	P28340
Wiki	POLD1

The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA), the multisubunit replication factor C, and the 4 subunit polymerase complex: POLD1, POLD2, POLD3, and POLD4.

The enzyme is 94% identical to bovine DNA polymerase delta and contains the numerous highly conserved regions previously observed in the bovine and yeast enzymes. The human enzyme also contains 2 putative zinc finger domains in the C-terminal region of the molecule as well as a putative nuclear localization signal at the N-terminal end.WRN functionally interacts with DNA polymerase delta, which is required for DNA replication and DNA repair.

Reference

"Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene."
Proc. Natl. Acad. Sci. U.S.A. 88:11197-11201(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta."
Nucleic Acids Res. 20:735-745(1992) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta."
Genes Cells 10:13-22(2005) [PubMed] [Europe PMC] [Abstract]

"Functional roles of p12, the fourth subunit of human DNA polymerase delta."
J. Biol. Chem. 281:14748-14755(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy."
Nat. Genet. 45:947-950(2013) [PubMed] [Europe PMC] [Abstract]

"CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis."
Nucleic Acids Res. 42:8433-8448(2014) [PubMed] [Europe PMC] [Abstract]

"Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas."
Nat. Genet. 45:136-144(2013) [PubMed] [Europe PMC] [Abstract]

"New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis."
Hum. Mol. Genet. 23:3506-3512(2014) [PubMed] [Europe PMC] [Abstract]