Phosphoglucomutase 5 (PGM5)

PGMRP; Phosphoglucomutase-Related Protein; Aciculin; Phosphoglucomutase-like protein 5

SPN	R082
HGNC	8908
MGI	1925668
PubMed	8586438
RGD	1307969
UniProt	Q15124
Wiki	PGM5

Phosphoglucomutases, such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen.

From a chromosome 6 library, they isolated a PGM-related expressed sequence with 74% nucleotide identity to PGM1. However, gene mapping data showed that the gene is a novel member of the PGM family, PGM5, from chromosome 9 rather than chromosome 6. RT-PCR and Northern blot analysis indicated that PGM5 is an expressed gene with widespread distribution in adult and fetal tissues.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterisation of the promoter which regulates expression of a phosphoglucomutase-related protein, a component of the dystrophin/utrophin cytoskeleton predominantly expressed in smooth muscle."
Eur. J. Biochem. 248:634-643(1997) [PubMed] [Europe PMC] [Abstract]