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Translocation Associated Membrane Protein 1 (TRAM1)

TRAM; TRAMP; Translocating chain-associated membrane protein 1

is a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. TRAM is a 374-amino acid, 8-pass transmembrane protein that shares 95% amino acid identity with the canine protein. TRAM contains a potential N-terminal N-linked glycosylation site and a C-terminal 60-residue cytosolic portion. Immunoblot analysis showed that TRAM is an abundantly expressed, approximately 36-kD microsomal glycoprotein. Functional analysis indicated that TRAM influences glycosylation and is stimulatory or required for the translocation of secretory proteins.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Hu01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Hu01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Hu01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Hu01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Hu01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Mu01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Mu01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Mu01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Mu01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Mu01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Ra01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Ra01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Ra01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Ra01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Ra01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Ca01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Ca01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Ca01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Ca01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Ca01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Po01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Po01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Po01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Po01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Po01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Bo01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Bo01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Bo01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Bo01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Bo01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Rb01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Rb01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Rb01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Rb01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Rb01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ982Mo01 Recombinant Translocation Associated Membrane Protein 1 (TRAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ982Mo01 Monoclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IP.
PAQ982Mo01 Polyclonal Antibody to Translocation Associated Membrane Protein 1 (TRAM1) WB; IHC; ICC; IF.
Assay Kits CLQ982Mo01 CLIA Kit for Translocation Associated Membrane Protein 1 (TRAM1) CLIA assay for Antigen Detection
ELQ982Mo01 ELISA Kit for Translocation Associated Membrane Protein 1 (TRAM1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A protein of the endoplasmic reticulum involved early in polypeptide translocation."
Nature 357:47-52(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein."
J. Biol. Chem. 284:5905-5914(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]