Secretogranin II (SCG2)
SN; SgII; CHGC; Chromogranin C; Secretoneurin
SCG2 is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.SCG2 also has 9 potential dibasic cleavage sites, an N-glycosylation site not found in the bovine protein, and a putative sulfation site (tyr121). SCG2 was predicted to assume a secondary structure of alternating helix and turn structures over 45% and 40% of its length, respectively. The authors suggested that this structure may coordinate calcium.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Hu01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Hu01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Hu01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Hu01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Hu01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Mu01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Mu01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Mu01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Mu01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Mu01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Ra01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Ra01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Ra01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Ra01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Ra01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Ca01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Ca01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Ca01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Ca01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Ca01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Po01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Po01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Po01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Po01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Po01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Bo01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Bo01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Bo01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Bo01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Bo01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Rb01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Rb01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Rb01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Rb01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Rb01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ947Mo01 | Recombinant Secretogranin II (SCG2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ947Mo01 | Monoclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IP. |
| PAQ947Mo01 | Polyclonal Antibody to Secretogranin II (SCG2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ947Mo01 | CLIA Kit for Secretogranin II (SCG2) | CLIA assay for Antigen Detection |
| ELQ947Mo01 | ELISA Kit for Secretogranin II (SCG2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation."
J. Biol. Chem. 264:12009-12015(1989) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains."
Neurosci. Lett. 248:105-108(1998) [PubMed] [Europe PMC] [Abstract]
"Phosphoproteomic analysis of the human pituitary."
Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]