Septin 6 (SEPT6)

SEP2

SPN	Q940
HGNC	15848
MGI	1888939
PubMed	8590280
RGD	1585082
UniProt	Q14141
Wiki	SEPT6

Septin-6 is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.

The deduced 424-amino acid protein shares 40% identity with CDC10 (SEPT7) and contains an ATP/GTP-binding site motif. Northern blot analysis detected nearly ubiquitous expression, with highest level in thymus.

Reference

"SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24."
Cancer Res. 62:333-337(2002) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]

"Expression profiling the human septin gene family."
J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]

"Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4."
Mol. Biol. Cell 16:4648-4659(2005) [PubMed] [Europe PMC] [Abstract]

"A mitotic septin scaffold required for mammalian chromosome congression and segregation."
Science 307:1781-1785(2005) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of septin 2, 6, and 7 complexes."
J. Biol. Chem. 281:30697-30706(2006) [PubMed] [Europe PMC] [Abstract]

"Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7."
Cell 130:837-850(2007) [PubMed] [Europe PMC] [Abstract]

"SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells."
J. Biochem. Mol. Biol. 40:973-978(2007) [PubMed] [Europe PMC] [Abstract]

"An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication."
J. Virol. 81:3852-3865(2007) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Septins regulate bacterial entry into host cells."
PLoS ONE 4:E4196-E4196(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structural insight into filament formation by mammalian septins."
Nature 449:311-315(2007) [PubMed] [Europe PMC] [Abstract]