Ribonucleotide Reductase M1 (RRM1)

R1; RIR1; RR1; Ribonucleoside-diphosphate reductase large subunit

SPN	Q891
HGNC	10451
MGI	98180
PubMed	23470290
RGD	1598288
UniProt	P23921
Wiki	RRM1

RRM1 encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.

Reference

"Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes."
Nucleic Acids Res. 19:3741-3741(1991) [PubMed] [Europe PMC] [Abstract]

"Sequence analysis of the large and small subunits of human ribonucleotide reductase."
DNA Seq. 2:227-234(1992) [PubMed] [Europe PMC] [Abstract]

"A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region."
Genomics 55:164-175(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene."
Genomics 19:91-96(1994) [PubMed] [Europe PMC] [Abstract]

"Human ribonucleotide reductase. Activation and inhibition by analogs of ATP."
Biochem. Pharmacol. 42:759-763(1991) [PubMed] [Europe PMC] [Abstract]

"Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits."
Cancer Res. 63:980-986(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits."
Biochem. Biophys. Res. Commun. 340:428-434(2006) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes."
Science 345:1512-1515(2014) [PubMed] [Europe PMC] [Abstract]

"Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization."
Nat. Struct. Mol. Biol. 18:316-322(2011) [PubMed] [Europe PMC] [Abstract]