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Reticulon 4 (RTN4)

NSP; ASY; NOGO; NSP-CL; RTN-X; Reticulon-5; Foocen; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog

Reticulon-4 is a protein belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Hu01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Hu01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Hu01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Hu01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Hu01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Mu01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Mu01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Mu01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Mu01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Mu01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Ra01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Ra01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Ra01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Ra01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Ra01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Ca01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Ca01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Ca01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Ca01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Ca01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Po01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Po01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Po01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Po01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Po01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Bo01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Bo01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Bo01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Bo01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Bo01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Rb01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Rb01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Rb01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Rb01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Rb01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ809Mo01 Recombinant Reticulon 4 (RTN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ809Mo01 Monoclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IP.
PAQ809Mo01 Polyclonal Antibody to Reticulon 4 (RTN4) WB; IHC; ICC; IF.
Assay Kits CLQ809Mo01 CLIA Kit for Reticulon 4 (RTN4) CLIA assay for Antigen Detection
ELQ809Mo01 ELISA Kit for Reticulon 4 (RTN4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping."
Cytogenet. Cell Genet. 88:101-102(2000) [PubMed] [Europe PMC] [Abstract]

"Inhibitor of neurite outgrowth in humans."
Nature 403:383-384(2000) [PubMed] [Europe PMC] [Abstract]

"A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity."
Oncogene 19:5736-5746(2000) [PubMed] [Europe PMC] [Abstract]

"Expression of a novel reticulon-like gene in human testis."
Reproduction 123:227-234(2002) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4."
J. Mol. Biol. 325:299-323(2003) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]