Histamine Receptor H4 (HRH4)

GPCR105; GPRv53; H4R; HH4R; H4; AXOR35; BG26; G-protein coupled receptor 105

SPN	Q762
HGNC	17383
MGI	2429635
PubMed	22363581
RGD	620631
UniProt	Q9H3N8

Histamine receptors are G protein-coupled receptors (GPCRs) that have distinct tissue expression profiles and functional attributes. They have varying sensitivities to an array of agonist and antagonist molecules that are used in pharmacologic studies and in treating different medical conditions. HRH4 is almost 40% identical to HRH3. It contains an asp residue in transmembrane domain-1 (TM1), a DRY motif in TM2, a disulfide bond between the first and third extracellular loops, a trp in TM4 and TM6, a pro in TM5 and TM6, an NPxxY motif in TM7, and a potential palmitoylation site in the C-terminal tail. Northern blot analysis revealed expression of a 4.5-kb transcript restricted to peripheral blood leukocytes. RT-PCR analysis detected expression in thymus, small intestine, spleen, and colon.

Reference

"Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes."
J. Biol. Chem. 275:36781-36786(2000) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of a new human histamine receptor, HH4R."
Biochem. Biophys. Res. Commun. 279:615-620(2000) [PubMed] [Europe PMC] [Abstract]

"Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow."
Mol. Pharmacol. 59:420-426(2001) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel human histamine receptor."
J. Pharmacol. Exp. Ther. 296:1058-1066(2001) [PubMed] [Europe PMC] [Abstract]

"Cloning, expression, and pharmacological characterization of a novel human histamine receptor."
Mol. Pharmacol. 59:434-441(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of a histamine H4 receptor on human eosinophils --role in eosinophil chemotaxis."
J. Recept. Signal Transduct. 22:431-448(2002) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor."
Biochem. J. 414:121-131(2008) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 18."
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]