Amyloid Beta Precursor Like Protein 1 (APLP1)

SPN	Q691
HGNC	597
MGI	88046
PubMed	21574595
RGD	69257
UniProt	P51693
Wiki	APLP1

APLP1 encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.

Reference

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Eur. J. Biochem. 250:354-363(1997) [PubMed] [Europe PMC] [Abstract]

"Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1."
Hum. Genet. 102:192-196(1998) [PubMed] [Europe PMC] [Abstract]

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Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density."
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"The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily."
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J. Biol. Chem. 274:2243-2254(1999) [PubMed] [Europe PMC] [Abstract]

"Evidence for a copper-binding superfamily of the amyloid precursor protein."
Biochemistry 41:9310-9320(2002) [PubMed] [Europe PMC] [Abstract]

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

"The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization."
Biochemistry 50:5453-5464(2011) [PubMed] [Europe PMC] [Abstract]