Heat Shock 40kDa Protein 2 (HSPF2)

DNAJC4; MCG18; HSP-F2; DnaJ(Hsp40)Homolog,Subfamily C,Member 4; DnaJ-like protein HSPF2; Multiple endocrine neoplasia type 1 candidate protein number 18

SPN	Q646
HGNC	5271
MGI	1927346
RGD	1308693
UniProt	Q9NNZ3

The E. coli heat-shock protein DnaJ is the founding member of a family of proteins that are associated with protein folding, complex assembly, and export. Prokaryotic and eukaryotic DnaJ homologs contain an approximately 70-amino acid J domain, which is thought to mediate interaction with 70-kD heat-shock proteins .

The HSPF2 gene is located approximately 250 bp centromeric of the VEGFB gene. The HSPF2 coding sequence is contained in 5 exons. The deduced 241-amino acid HSPF2 protein has a J domain followed by a predicted transmembrane domain. The human and mouse HSPF2 proteins are 71% identical. Northern blot analysis detected an approximately 1.4-kb HSPF2 transcript in all human cell lines examined.

Reference

"Characterisation of a new human and murine member of the DnaJ family of proteins."
Biochem. Biophys. Res. Commun. 243:273-276(1998) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]