Dedicator Of Cytokinesis 3 (DOCK3)

MOCA; PBP; Modifier of cell adhesion; Presenilin-binding protein

SPN	Q624
HGNC	2989
MGI	2429763
PubMed	10854253
RGD	1306677
UniProt	Q8IZD9
Wiki	Dock3

Dock3 was originally discovered in a screen for proteins that bind presenilin (a transmembrane protein which is mutated in early onset Alzheimer's disease).Dock3 is specifically expressed in neurones (primarily in the cerebral cortex and hippocampus).Dock3 is part of a large class of proteins (GEFs) which contibrute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by promoting this nucleotide exchange.Dock3 exhibits the same domain arrangement as Dock180 and these proteins share a considerable (40%) degree of sequence similarity.

Reference

"Isolation and characterization of novel presenilin binding protein."
J. Neurochem. 75:109-116(2000) [PubMed] [Europe PMC] [Abstract]

"Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype."
J. Med. Genet. 40:733-740(2003) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]

"Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation."
Am. J. Pathol. 159:1597-1602(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]