Forkhead Box Protein A2 (FOXA2)

FOX-A2; HNF3B; TCF3B; Hepatocyte Nuclear Factor 3,Beta; Transcription factor 3B

SPN	Q599
HGNC	5022
MGI	1347476
PubMed	20483781
RGD	2808
UniProt	Q9Y261
Wiki	FOXA2

FOXA2 encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin.

FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. The genes encode polypeptides of 468, 459, and 354 amino acids, respectively. Both HNF3A and HNF3B are expressed in tissues of endodermal origin, i.e., stomach, intestines, liver, and lung, HNF3G is more extensively expressed, being present additionally in ovary, testis, heart, and adipose tissue, but missing from lung.

Reference

"Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young."
Diabetologia 43:121-124(2000) [PubMed] [Europe PMC] [Abstract]

"The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."
Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization."
Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003) [PubMed] [Europe PMC] [Abstract]

"A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism."
J. Biol. Chem. 280:16763-16771(2005) [PubMed] [Europe PMC] [Abstract]

"Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."
Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]

"Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2."
J. Biol. Chem. 284:19915-19926(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]