Hydroxyacylglutathione Hydrolase (HAGH)

GLO2; GLX2; GLXII; HAGH1; Glyoxalase II; Hydroxyacyl Glutathione Hydrolase

SPN	Q566
HGNC	4805
MGI	95745
PubMed	3025077
RGD	2779
UniProt	Q16775
Wiki	HAGH

Glyoxalase II, otherwise known as hydroxyacyl-glutathione hydrolase, converts the intermediate substrate S-lactoyl-glutathione to reduced glutathione and D-lactate. By study of somatic cell hybrids, Honey and Shows (1981) concluded that the gene for glyoxalase II is on chromosome 16. Mulley and Callen (1986) confirmed the assignment of HAGH to chromosome 16 by studies of a human-mouse hybrid panel. They found that both HAGH and phosphoglycolate phosphatase (PGP) were present only in those cell lines containing 16p13. Board (1980) described rare polymorphism, observed only in a Micronesian population in which a new variant allele had a frequency of 0.016. In the heterozygotes, the electrophoretic pattern was a double band, suggesting that the structure of glyoxalase II is monomeric.

Reference

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J. Biol. Chem. 271:319-323(1996) [PubMed] [Europe PMC] [Abstract]

"The human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II."
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