Immediate Early Response 3 (IER3)

PRG1; DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1; Radiation-inducible immediate-early gene IEX-1; Differentiation-dependent gene 2 protein; PACAP-responsive gene 1 protein

SPN	Q558
HGNC	5392
MGI	104814
PubMed	8603392
RGD	1303321
UniProt	P46695
Wiki	IER3

IER3 had an in-frame insertion of 111 nucleotides at position 211 of the coding region of IEX1, and could encode a longer polypeptide with a 37-amino acid insertion relative to IEX1. The longer IEX1 (referred to as IEX1L; the original IEX1 was referred to as IEX1S) was found to be generated from IEX1 in the absence of RNA splicing as it contained the entire intron sequence of IEX1. The transcription of IEX1L induced by TNF was decreased in cells with defective NF-kappa-B activation, rendering them sensitive to TNF-induced apoptosis, which was abolished by transfection with IEX1L. In support, overexpression of antisense IEX1L partially blocked TNF-induced expression of IEX1L and sensitized normal cells to killing. This study demonstrated a key role of IEX1L in cellular resistance to TNF-induced apoptosis.

Reference

"Identification and characterization of a radiation-inducible glycosylated human early-response gene."
Cancer Res. 56:1498-1502(1996) [PubMed] [Europe PMC] [Abstract]

"PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line."
Cancer Res. 56:2641-2648(1996) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine."
Biochem. Biophys. Res. Commun. 235:4-9(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation."
EMBO J. 21:5151-5163(2002) [PubMed] [Europe PMC] [Abstract]

"B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK."
EMBO J. 25:727-738(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis."
J. Clin. Invest. 122:2092-2103(2012) [PubMed] [Europe PMC] [Abstract]