Proteasome 26S Subunit, ATPase 3 (PSMC3)

TBP1; Tat-binding protein 1; Proteasome subunit P50; 26S proteasome AAA-ATPase subunit RPT5

SPN	Q536
HGNC	9549
MGI	1098754
PubMed	9048938
RGD	61905
UniProt	P17980
Wiki	PSMC3

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.

PSMC3 encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Reference

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, Submitted (DEC-2008) to UniProtKB

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