Protein Kinase, AMP Activated Beta 2 (PRKAb2)

5'-AMP-activated protein kinase subunit beta-2

SPN	Q525
HGNC	9379
MGI	1336185
PubMed	16505254
RGD	620905
UniProt	O43741
Wiki	PRKAB2

5'-AMP-activated protein kinase subunit beta-2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status.

In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.

Reference

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