Guanylate Cyclase Activator 2B (GUCA2B)
UGN; GCAP-II; Uroguanylin; Guanylate cyclase C-activating peptide II
Uroguanylin and guanylin (GUCA2A), peptide homologs of the bacterial heat-stable enterotoxins (e.g., the E. coli ST toxin; STa), are endogenous activators of the guanylate cyclase-2C receptor (GUCY2C), which synthesizes cyclic GMP (cGMP), a key component of several intracellular signal transduction pathways.The 16 C-terminal amino acids are identical to uroguanylin, and 8 of 13 C-terminal residues are conserved between GCAP II, uroguanylin, and E. coli STa.
The GUCA2B gene also has multiple binding sites for the promoter-specific transcription factors AP1 and AP2, and a cAMP-regulated enhancer element. In the mouse, uroguanylin mRNA is most prominent in the proximal small intestine, whereas guanylin mRNA is predominantly expressed in distal small intestine and colon.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Hu01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Hu01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Hu01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Hu01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Hu01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Mu01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Mu01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Mu01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Mu01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Mu01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Ra01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Ra01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Ra01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Ra01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Ra01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Ca01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Ca01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Ca01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Ca01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Ca01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Po01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Po01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Po01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Po01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Po01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Bo01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Bo01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Bo01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Bo01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Bo01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Rb01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Rb01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Rb01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Rb01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Rb01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ520Mo01 | Recombinant Guanylate Cyclase Activator 2B (GUCA2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ520Mo01 | Monoclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IP. |
| PAQ520Mo01 | Polyclonal Antibody to Guanylate Cyclase Activator 2B (GUCA2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ520Mo01 | CLIA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | CLIA assay for Antigen Detection |
| ELQ520Mo01 | ELISA Kit for Guanylate Cyclase Activator 2B (GUCA2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of a cDNA encoding a precursor for human uroguanylin."
Biochem. Biophys. Res. Commun. 219:644-648(1996) [PubMed] [Europe PMC] [Abstract]
"A new human guanylate cyclase-activating peptide (GCAP-II, uroguanylin): precursor cDNA and colonic expression."
Biochim. Biophys. Acta 1253:146-149(1995) [PubMed] [Europe PMC] [Abstract]
"Genomic structure and chromosomal localization of human uroguanylin."
Genomics 43:359-365(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"GCAP-II: isolation and characterization of the circulating form of human uroguanylin."
FEBS Lett. 374:34-38(1995) [PubMed] [Europe PMC] [Abstract]
"Characterization of human uroguanylin: a member of the guanylin peptide family."
Am. J. Physiol. 266:F342-F348(1994) [PubMed] [Europe PMC] [Abstract]
"One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers."
J. Pept. Res. 52:229-240(1998) [PubMed] [Europe PMC] [Abstract]