Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)

CCN1; GIG1; IGFBP10; CCN family member 1; Insulin-like growth factor-binding protein 10

SPN	Q499
HGNC	2654
MGI	88613
PubMed	22547695
RGD	620763
UniProt	O00622
Wiki	CYR61

CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.

The transcription of immediate-early genes is induced rapidly when cells are stimulated by growth factors or transforming oncogenes.The human CYR61 gene encodes a predicted 382-amino acid protein that is 93% identical to the mouse protein, and contains 10% cysteine residues and a 24-amino acid N-terminal signal sequence. Northern blot analysis revealed 2.5-kb and minor 4-kb CYR61 mRNAs that are expressed widely at varying levels.

Reference

"The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p."
Oncogene 14:1753-1757(1997) [PubMed] [Europe PMC] [Abstract]

"Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system."
Mol. Pathol. 50:310-316(1997) [PubMed] [Europe PMC] [Abstract]

"Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61."
J. Biol. Chem. 275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract]

"Organization and expression of the Cyr61 gene in normal human fibroblasts."
J. Biomed. Sci. 9:59-67(2002) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts."
J. Biol. Chem. 276:47329-47337(2001) [PubMed] [Europe PMC] [Abstract]

"Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3."
J. Biol. Chem. 273:3090-3096(1998) [PubMed] [Europe PMC] [Abstract]

"Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)."
J. Biol. Chem. 274:24321-24327(1999) [PubMed] [Europe PMC] [Abstract]

"Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans."
J. Biol. Chem. 275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract]

"CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain."
J. Biol. Chem. 276:21943-21950(2001) [PubMed] [Europe PMC] [Abstract]