Corin (CRN)

ATC2; CRN; Lrp4; TMPRSS10; Atrial Natriuretic Peptide-Converting Enzyme, Serine Protease; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme

SPN	Q496
HGNC	19012
MGI	1349451
PubMed	22437503
RGD	727887
UniProt	Q9Y5Q5

Corin encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.

The corin cDNA encodes a deduced 1,042-amino acid, type II transmembrane protein. At its N terminus, corin contains a short cytoplasmic domain and a transmembrane sequence. In the extracellular region of corin, there are 2 frizzled-like cysteine-rich motifs, 7 low density lipoprotein receptor repeats, a macrophage scavenger receptor-like domain, and a trypsin-like protease domain at the C terminus.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Hu01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Hu01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Hu01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Hu01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Hu01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Mu01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Mu01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Mu01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Mu01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Mu01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Ra01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Ra01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Ra01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Ra01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Ra01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Ca01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Ca01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Ca01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Ca01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Ca01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Po01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Po01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Po01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Po01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Po01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Bo01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Bo01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Bo01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Bo01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Bo01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Rb01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Rb01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Rb01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Rb01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Rb01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ496Mo01	Recombinant Corin (CRN)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ496Mo01	Monoclonal Antibody to Corin (CRN)	WB; IHC; ICC; IP.
Antibodies	PAQ496Mo01	Polyclonal Antibody to Corin (CRN)	WB; IHC; ICC; IF.
Assay Kits	CLQ496Mo01	CLIA Kit for Corin (CRN)	CLIA assay for Antigen Detection
Assay Kits	ELQ496Mo01	ELISA Kit for Corin (CRN)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart."
J. Biol. Chem. 274:14926-14935(1999) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Localization of the mosaic transmembrane serine protease corin to heart myocytes."
Eur. J. Biochem. 267:6931-6937(2000) [PubMed] [Europe PMC] [Abstract]

"Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme."
Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000) [PubMed] [Europe PMC] [Abstract]

"Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin."
J. Biol. Chem. 278:52363-52370(2003) [PubMed] [Europe PMC] [Abstract]

"Role of glycosylation in corin zymogen activation."
J. Biol. Chem. 282:27728-27735(2007) [PubMed] [Europe PMC] [Abstract]

"Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood."
Clin. Chim. Acta 409:85-89(2009) [PubMed] [Europe PMC] [Abstract]

"Ectodomain shedding and autocleavage of the cardiac membrane protease corin."
J. Biol. Chem. 286:10066-10072(2011) [PubMed] [Europe PMC] [Abstract]

"Human corin isoforms with different cytoplasmic tails that alter cell surface targeting."
J. Biol. Chem. 286:20963-20969(2011) [PubMed] [Europe PMC] [Abstract]

"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy."
Nature 484:246-250(2012) [PubMed] [Europe PMC] [Abstract]

"An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss."
Hum. Mutat. 29:130-141(2008) [PubMed] [Europe PMC] [Abstract]