Statherin (STATH)

STR

SPN	Q371
HGNC	11369
PubMed	15041485
UniProt	P02808
Wiki	STATH

Statherin may play an important role in the maintenance of oral health since, like the proline-rich proteins, it binds calcium and inhibits crystal growth. Statherin also inhibits spontaneous precipitation of calcium phosphate salts. Thus, statherin and PRPs may prevent build-up of harmful deposits in the salivary glands and on the tooth surfaces.

Statherin is a highly stable salivary protein of low molecular mass (5,380). Sabatini et al. synthesized mixed oligonucleotides based on the known amino acid sequence of statherin and used these to screen a cDNA library constructed from human parotid gland mRNA. A study of DNA from human-hamster somatic cell hybrids indicated that statherin is coded by a single-copy gene located in region 4q11-q13. Dentinogenesis imperfectaand perhaps juvenile periodontitis are coded in the same region.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Hu01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Hu01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Hu01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Hu01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Hu01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Mu01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Mu01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Mu01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Mu01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Mu01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Ra01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Ra01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Ra01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Ra01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Ra01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Ca01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Ca01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Ca01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Ca01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Ca01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Po01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Po01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Po01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Po01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Po01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Bo01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Bo01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Bo01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Bo01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Bo01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Rb01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Rb01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Rb01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Rb01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Rb01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ371Mo01	Recombinant Statherin (STATH)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ371Mo01	Monoclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IP.
Antibodies	PAQ371Mo01	Polyclonal Antibody to Statherin (STATH)	WB; IHC; ICC; IF.
Assay Kits	CLQ371Mo01	CLIA Kit for Statherin (STATH)	CLIA assay for Antigen Detection
Assay Kits	ELQ371Mo01	ELISA Kit for Statherin (STATH)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva."
Am. J. Hum. Genet. 41:1048-1060(1987) [PubMed] [Europe PMC] [Abstract]

"Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence."
Biochem. Biophys. Res. Commun. 149:784-790(1987) [PubMed] [Europe PMC] [Abstract]

"Structure and sequence determination of the gene encoding human salivary statherin."
Gene 89:245-251(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva."
J. Biol. Chem. 252:1689-1695(1977) [PubMed] [Europe PMC] [Abstract]

"Multiple forms of statherin in human salivary secretions."
Arch. Oral Biol. 36:529-534(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides."
J. Dent. Res. 66:462-466(1987) [PubMed] [Europe PMC] [Abstract]

"Tyrosine sulfation of statherin."
Int. J. Biol. Sci. 3:237-241(2007) [PubMed] [Europe PMC] [Abstract]

"HPLC-MS characterization of cyclo-statherin Q-37, a specific cyclization product of human salivary statherin generated by transglutaminase 2."
J. Sep. Sci. 29:2600-2608(2006) [PubMed] [Europe PMC] [Abstract]