Dipeptidyl Peptidase 10 (DPP10)

DPL2; DPPY; DPRP3; Dipeptidylpeptidase 10(Non-Functional); Dipeptidyl peptidase IV-related protein 3; Dipeptidyl peptidase X; Dipeptidyl peptidase-like protein 2

SPN	Q369
HGNC	20823
MGI	2442409
PubMed	15671030
RGD	1306427
UniProt	Q8N608
Wiki	DPP10

DPP10 encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. DPP10 lacks the active-site serine, which is substituted with a glycine residue. Database analysis suggested the presence of a second DPP10 transcript. DPP10 shares 48% and 51% amino acid identity with the short and long DPP6 isoforms, respectively.

Reference

"Dipeptidyl peptidase IV gene family. The DPIV family."
Adv. Exp. Med. Biol. 524:79-86(2003) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases."
Biochem. J. 373:179-189(2003) [PubMed] [Europe PMC] [Abstract]

"Positional cloning of a novel gene influencing asthma from chromosome 2q14."
Nat. Genet. 35:258-263(2003) [PubMed] [Europe PMC] [Abstract]

"Species and tissue differences in the expression of DPPY splicing variants."
Biochem. Biophys. Res. Commun. 348:1094-1100(2006) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."
Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]

"DPP10 modulates Kv4-mediated A-type potassium channels."
J. Biol. Chem. 280:18853-18861(2005) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort."
Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract]

"N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels."
Int. J. Biochem. Cell Biol. 44:876-885(2012) [PubMed] [Europe PMC] [Abstract]