Dipeptidyl Peptidase 7 (DPP7)

DPP2; DPPII; QPP; Dipeptidylpeptidase 7

SPN	Q366
HGNC	14892
MGI	1933213
PubMed	15487984
RGD	71073
UniProt	Q9UHL4
Wiki	DPP7

Dipeptidyl-peptidase 2 is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.predicted 492-amino acid protein has a calculated molecular mass of 54.3 kD and contains the consensus sequence for the active-site serine residue of serine-type proteases. It shares 42% amino acid identity with the carboxypeptidase PRCP, with higher identity at the putative active-site residues. Northern blot analysis detected a 1.7-kb transcript in PBMCs and Jurkat T cells. SDS-PAGE analysis showed expression of a 58-kD protein.

Reference

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