Secretoglobin Family 3A, Member 1 (SCGB3A1)

HIN1; HIN-1; LU105; PnSP-2; UGRP2; Cytokine High In Normal-1; Pneumo Secretory Protein 2; High in normal 1; Uteroglobin-related protein 2

SPN	Q308
HGNC	18384
MGI	1915912
PubMed	12406855
RGD	727901
UniProt	Q96QR1
Wiki	SCGB3A1

Breast cancer progresses from atypical hyperproliferation to in situ and then invasive carcinomas before culminating in metastatic disease. Ductal carcinoma in situ (DCIS) is thought to be the precursor of invasive ductal carcinoma. The deduced 104-amino acid HIN1 protein contains a signal peptide and is conserved in several species. HIN1 was highly expressed in breast tissue from a woman in the twenty-fifth week of pregnancy. In situ hybridization analysis confirmed the expression of HIN1 in small ducts and lobules, irrespective of their proliferation and hormone receptor status. HIN1 was also highly expressed in other tissues with branching ductal epithelia. No expression was detected in large or DCIS ducts. Western blot analysis showed expression of an 8-kD protein.

Reference

"HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells."
Proc. Natl. Acad. Sci. U.S.A. 98:9796-9801(2001) [PubMed] [Europe PMC] [Abstract]

"UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor."
Mol. Endocrinol. 15:2021-2036(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]