V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN)

JTK8; p53Lyn; p56Lyn; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase

SPN	Q282
HGNC	6735
MGI	96892
PubMed	3561390
RGD	621017
UniProt	P07948
Wiki	LYN

Using a v-yes DNA as the probe, Yamanashi et al. (1987) screened a human cDNA library made from placental RNA and derived DNA clones representing a novel genetic locus termed LYN. Nucleotide sequencing showed that LYN encodes a novel tyrosine kinase. Northern hybridization analysis showed that a 3.2-kb LYN mRNA was expressed in a variety of tissues of the human fetus. The pattern of expression was different from those of related genes such as YES.The degranulation response was dependent on a rise in intracellular calcium that was inhibited in Lyn-deficient mast cells but intact in Fyn-deficient cells. Degranulation proceeded in Lyn -/- cells due to increased activation and constitutive phosphorylation of the calcium-independent protein kinase C delta isoform (PRKCD).

Reference

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