Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK)
RIPK5; Dusty PK; RIP5; SgK496; Receptor Interacting Protein Kinase 5; RIP-homologous kinase; Sugen kinase 496; Receptor-interacting serine/threonine-protein kinase 5
The deduced 929-amino acid protein contains a C-terminal kinase domain, which shares homology with the kinase domain of RIPK family members. Northern blot analysis of human tissues detected weak expression in heart, brain, placenta, skeletal muscle, kidney, pancreas, and testis.
DSTYK failed to activate NF-kappa-B (NFKB1) in a reporter gene assay. Overexpression of DSTYK induced DNA fragmentation and cell death in a dose-dependent manner with cell death occurring approximately 30 hours after transfection. Caspase inhibitory protein and morphologic studies showed that DSTYK induced both caspase-dependent and caspase-independent cell death, and both the N- and C-terminal DSTYK deletion mutants retained the ability to induce cell death.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Hu01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Hu01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Hu01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Hu01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Hu01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Mu01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Mu01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Mu01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Mu01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Mu01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Ra01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Ra01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Ra01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Ra01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Ra01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Ca01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Ca01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Ca01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Ca01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Ca01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Po01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Po01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Po01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Po01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Po01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Bo01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Bo01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Bo01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Bo01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Bo01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Rb01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Rb01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Rb01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Rb01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Rb01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ278Mo01 | Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ278Mo01 | Monoclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IP. |
| PAQ278Mo01 | Polyclonal Antibody to Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ278Mo01 | CLIA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | CLIA assay for Antigen Detection |
| ELQ278Mo01 | ELISA Kit for Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
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N. Engl. J. Med. 369:621-629(2013) [PubMed] [Europe PMC] [Abstract]