Chordin Like Protein 2 (CHRDL2)
BNF1; CHL2; Breast Tumor Novel Factor 1; Chordin-related protein 2
The deduced 429-amino acid human protein shares 73% homology with the 426-amino acid mouse protein. CHL2 contains an N-terminal signal peptide, followed by 3 chordin (CHRD)-like cysteine-rich repeats (CR1 through CR3) and a C-terminal tail. Northern blot analysis detected high expression of a 2.0-kb CHL2 transcript in adult human uterus, with lower expression in colon, heart, prostate, stomach, and skeletal muscle. Expression was weak in placenta, testis, small intestine, trachea, and bone marrow, and no expression was detected in liver or kidney. In situ hybridization of mouse embryos showed that Chl2 expression was restricted to chondrocytes of developing joint cartilage. In adult mice, Chl2 expression was detected in connective tissues of reproductive organs, with highest expression in uterine myometrium.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Hu01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Hu01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Hu01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Hu01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Hu01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Mu01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Mu01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Mu01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Mu01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Mu01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Ra01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Ra01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Ra01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Ra01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Ra01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Ca01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Ca01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Ca01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Ca01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Ca01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Po01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Po01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Po01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Po01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Po01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Bo01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Bo01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Bo01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Bo01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Bo01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Rb01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Rb01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Rb01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Rb01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Rb01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ112Mo01 | Recombinant Chordin Like Protein 2 (CHRDL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ112Mo01 | Monoclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IP. |
| PAQ112Mo01 | Polyclonal Antibody to Chordin Like Protein 2 (CHRDL2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ112Mo01 | CLIA Kit for Chordin Like Protein 2 (CHRDL2) | CLIA assay for Antigen Detection |
| ELQ112Mo01 | ELISA Kit for Chordin Like Protein 2 (CHRDL2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues."
Gene 311:105-110(2003) [PubMed] [Europe PMC] [Abstract]
"hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation."
Gene 331:17-31(2004) [PubMed] [Europe PMC] [Abstract]
"A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage."
Development 131:229-240(2004) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]