Phosphodiesterase 1A, Calmodulin Dependent (PDE1A)

hCam-1; 61 kDa Cam-PDE; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

SPN	Q103
HGNC	8774
MGI	1201792
PubMed	12135876
RGD	68329
UniProt	P54750
Wiki	PDE1A

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin -dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+).

The predicted 535-amino acid PDE1A protein is 94% identical to the bovine 61-kD CaM-PDE when 2 short regions unique to PDE1A are excluded from comparison. Northern blot analysis revealed tissue-specific expression of 4.8-, 2.4-, and 2.6-kb PDE1A mRNAs, with transcripts most abundant in brain, heart, kidney, and skeletal muscle.

Reference

"Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases."
J. Biol. Chem. 271:796-806(1996) [PubMed] [Europe PMC] [Abstract]

"Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization."
Biochim. Biophys. Acta 1517:278-287(2001) [PubMed] [Europe PMC] [Abstract]

"Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants."
Cell. Signal. 14:53-60(2002) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]