Tropomodulin 1 (TMOD1)
ETMOD; TMOD; Erythrocyte tropomodulin
TMOD1 encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton.
TMOD gene is expressed in major human tissues at different levels in the following order: heart and skeletal muscle much greater than in brain, lung, and pancreas, which is greater than in placenta, liver, and kidney. They pointed to structural similarities between tropomodulin and the 64-kD autoantigen in Graves disease and suggested that the 2 genes evolved from a common ancestral gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Hu01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Hu01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Hu01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Hu01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Hu01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Mu01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Mu01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Mu01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Mu01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Mu01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Ra01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Ra01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Ra01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Ra01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Ra01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Ca01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Ca01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Ca01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Ca01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Ca01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Po01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Po01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Po01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Po01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Po01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Bo01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Bo01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Bo01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Bo01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Bo01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Rb01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Rb01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Rb01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Rb01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Rb01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ071Mo01 | Recombinant Tropomodulin 1 (TMOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ071Mo01 | Monoclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IP. |
| PAQ071Mo01 | Polyclonal Antibody to Tropomodulin 1 (TMOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ071Mo01 | CLIA Kit for Tropomodulin 1 (TMOD1) | CLIA assay for Antigen Detection |
| ELQ071Mo01 | ELISA Kit for Tropomodulin 1 (TMOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein."
J. Biol. Chem. 267:2616-2621(1992) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments."
Gene 256:271-281(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene."
Biochem. Biophys. Res. Commun. 201:627-634(1994) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy."
J. Clin. Invest. 124:4693-4708(2014) [PubMed] [Europe PMC] [Abstract]