G Protein Coupled Receptor 78 (GPR78)

SPN	Q022
HGNC	4528
PubMed	16389273
UniProt	Q96P69
Wiki	GPR78

The response depended upon the cell line studied. UV-B was a weaker inducer, and UV-C and several other DNA-damaging agents did not induce GPR78 expression. Induction of GPR78 by tunicamycin required activation of multiple ER stress-response elements in the promoter of the GPR78 gene, and induction by a DNA-alkylating agent was independent of the unfolded protein response.

GPR78 encodes a deduced 363-amino acid protein that shares 56% sequence identity with GPR26 in the transmembrane region. Northern blot analysis revealed a 1.1-kb transcript in pituitary, and 1.1- and 4.2-kb transcripts in placenta. No expression was detected in brain, skeletal muscle, lung, heart, liver, pancreas, or kidney.

Reference

"Discovery and mapping of ten novel G protein-coupled receptor genes."
Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78."
Biochim. Biophys. Acta 1770:890-901(2007) [PubMed] [Europe PMC] [Abstract]