TNF Receptor Associated Factor 4 (TRAF4)

CART1; MLN62; RNF83; Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; RING finger protein 83

SPN	P995
HGNC	12034
MGI	1202880
PubMed	22547678
RGD	1306708
UniProt	Q9BUZ4
Wiki	TRAF4

TRAF4 encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily.

The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.

Reference

"Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."
Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma."
J. Biol. Chem. 270:25715-25721(1995) [PubMed] [Europe PMC] [Abstract]

"TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues."
Am. J. Pathol. 152:1549-1561(1998) [PubMed] [Europe PMC] [Abstract]

"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction."
J. Biol. Chem. 274:30202-30208(1999) [PubMed] [Europe PMC] [Abstract]

"Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase."
J. Biol. Chem. 277:28051-28057(2002) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase."
Leuk. Res. 27:687-694(2003) [PubMed] [Europe PMC] [Abstract]

"TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF."
Eur. J. Immunol. 35:2477-2485(2005) [PubMed] [Europe PMC] [Abstract]

"MEKK4 is an effector of the embryonic TRAF4 for JNK activation."
J. Biol. Chem. 280:35793-35796(2005) [PubMed] [Europe PMC] [Abstract]

"Subcellular targeting of oxidants during endothelial cell migration."
J. Cell Biol. 171:893-904(2005) [PubMed] [Europe PMC] [Abstract]

"TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN."
Cancer Biol. Ther. 6:1986-1990(2007) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis."
PLoS ONE 3:E3518-E3518(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."
Mol. Cell. Biochem. 338:11-17(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Solution structure of TRAF-type zinc finger domains from human TNF receptor-associated factor 4."
Submitted (APR-2008) to the PDB data bank