Polo Like Kinase 2 (PLK2)

SNK; Serum-Inducible Kinase; Serine/threonine-protein kinase PLK2; Serine/threonine-protein kinase SNK

SPN	P962
HGNC	19699
MGI	1099790
PubMed	20802490
RGD	620760
UniProt	Q9NYY3
Wiki	PLK2

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division.

The deduced 685-amino acid protein has a calculated molecular mass of about 78 kD and contains an ATP-binding motif within the kinase domain and a conserved polo box. SNK shares about 97% sequence identity with the mouse and rat proteins. Dot blot analysis indicated a ubiquitous low level of SNK expression. Highest expression was found in adult testis, spleen, putamen, and occipital lobe, and in fetal lung, spleen, kidney, and heart.The International Radiation Hybrid Mapping Consortium mapped the SNK gene to chromosome 5

Reference

"Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase."
DNA Seq. 11:527-533(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells."
Biochem. Biophys. Res. Commun. 289:491-498(2001) [PubMed] [Europe PMC] [Abstract]

"Polo-like kinase-2 is required for centriole duplication in mammalian cells."
Curr. Biol. 14:1200-1207(2004) [PubMed] [Europe PMC] [Abstract]

"Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies."
Blood 107:250-256(2006) [PubMed] [Europe PMC] [Abstract]

"Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain."
Cell Cycle 7:3548-3555(2008) [PubMed] [Europe PMC] [Abstract]

"Distinct microRNA expression profiles in acute myeloid leukemia with common translocations."
Proc. Natl. Acad. Sci. U.S.A. 105:15535-15540(2008) [PubMed] [Europe PMC] [Abstract]

"PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle."
EMBO J. 29:2395-2406(2010) [PubMed] [Europe PMC] [Abstract]

"Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication."
PLoS ONE 5:E9849-E9849(2010) [PubMed] [Europe PMC] [Abstract]

"Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions."
Ann. Hematol. 90:1037-1045(2011) [PubMed] [Europe PMC] [Abstract]

"Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy."
Nat. Rev. Drug Discov. 9:643-660(2010) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]