Transcobalamin II, Macrocytic Anemia (TCN2)

TC2; Transcobalamin II

SPN	P952
HGNC	11653
MGI	98534
PubMed	12911562
RGD	620681
UniProt	P20062

TCN2 encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene.

Deficiency in TC II was demonstrated. A partial deficiency in both parents and other hematologically normal relatives indicated autosomal recessive inheritance. Decreased intestinal absorption of B12, uncorrected by intrinsic factor, suggested that transcobalamin II is involved in B12 absorption.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Hu01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Hu01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Hu01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Hu01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Hu01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Mu01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Mu01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Mu01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Mu01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Mu01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Ra01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Ra01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Ra01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Ra01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Ra01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Ca01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Ca01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Ca01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Ca01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Ca01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Po01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Po01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Po01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Po01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Po01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Bo01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Bo01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Bo01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Bo01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Bo01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Rb01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Rb01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Rb01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Rb01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Rb01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP952Mo01	Recombinant Transcobalamin II, Macrocytic Anemia (TCN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP952Mo01	Monoclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IP.
Antibodies	PAP952Mo01	Polyclonal Antibody to Transcobalamin II, Macrocytic Anemia (TCN2)	WB; IHC; ICC; IF.
Assay Kits	CLP952Mo01	CLIA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	CLIA assay for Antigen Detection
Assay Kits	ELP952Mo01	ELISA Kit for Transcobalamin II, Macrocytic Anemia (TCN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I."
J. Biol. Chem. 266:7860-7863(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation and sequence analysis of variant forms of human transcobalamin II."
Biochim. Biophys. Acta 1172:21-30(1993) [PubMed] [Europe PMC] [Abstract]

"The cloning and characterization of the human transcobalamin II gene."
Blood 85:2711-2719(1995) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and molecular characterization of human transcobalamin II."
J. Biol. Chem. 261:15455-15460(1986) [PubMed] [Europe PMC] [Abstract]

"Functional human transcobalamin II isoproteins are secreted by insect cells using the baculovirus expression system."
Blood 81:1239-1245(1993) [PubMed] [Europe PMC] [Abstract]

"Structural basis for mammalian vitamin B12 transport by transcobalamin."
Proc. Natl. Acad. Sci. U.S.A. 103:4386-4391(2006) [PubMed] [Europe PMC] [Abstract]

"Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood."
Blood 97:1092-1098(2001) [PubMed] [Europe PMC] [Abstract]