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Lysine Specific Demethylase 4A (KDM4A)

JMJD2; JMJD2A; JHDM3A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A

JMJD2A encodes a deduced 1,064-amino acid protein. Like JMJD2B and JMJD2C, JMJD2A contains a JmjN domain, a JmjC domain, a JD2H domain, 2 TUDOR domains, and a bipartite nuclear localization signal that overlaps the C-terminal part of the second TUDOR domain. JmjN is a small domain found in the Jumonji family of transcription factors. JmjC is a putative enzymatic domain. JD2H is a region containing 2 cys-his clusters with weak similarity to a PHD domain.This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Hu01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Hu01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Hu01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Hu01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Hu01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Mu01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Mu01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Mu01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Mu01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Mu01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Ra01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Ra01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Ra01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Ra01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Ra01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Ca01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Ca01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Ca01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Ca01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Ca01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Po01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Po01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Po01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Po01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Po01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Bo01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Bo01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Bo01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Bo01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Bo01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Rb01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Rb01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Rb01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Rb01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Rb01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP941Mo01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP941Mo01 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAP941Mo01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IF.
Assay Kits CLP941Mo01 CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA assay for Antigen Detection
ELP941Mo01 ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein."
J. Biol. Chem. 280:28507-28518(2005) [PubMed] [Europe PMC] [Abstract]

"JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)."
Mol. Cell. Biol. 25:6404-6414(2005) [PubMed] [Europe PMC] [Abstract]

"Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases."
Cell 125:467-481(2006) [PubMed] [Europe PMC] [Abstract]

"Tudor, MBT and chromo domains gauge the degree of lysine methylation."
EMBO Rep. 7:397-403(2006) [PubMed] [Europe PMC] [Abstract]

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"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites."
EMBO J. 31:1865-1878(2012) [PubMed] [Europe PMC] [Abstract]

"A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation."
PLoS Genet. 7:E1001390-E1001390(2011) [PubMed] [Europe PMC] [Abstract]

"Structural insights into histone demethylation by JMJD2 family members."
Cell 125:691-702(2006) [PubMed] [Europe PMC] [Abstract]

"Recognition of histone H3 lysine-4 methylation by the double Tudor domain of JMJD2A."
Science 312:748-751(2006) [PubMed] [Europe PMC] [Abstract]