Glycosylphosphatidylinositol Anchored Molecule Like Protein (GML)

LY6DL; GPI Anchored Molecule Like Protein

SPN	P916
HGNC	4375
UniProt	Q99445

Furuhata et al. (1996) identified a gene encoding a predicted 158-amino acid protein that is induced by p53 . Because of its homology to glycosylphosphatidylinositol (GPI)-anchored membrane proteins, Furuhata et al. (1996) designated the gene 'GPI-anchored molecule-like protein,' or GML. By Northern blot and RT-PCR analysis, Furuhata et al. (1996) found that GML is expressed as a less than 1-kb mRNA in many tissues, including testis.

Expression of GML suppressed the growth of esophageal cancer cells in culture. Furuhata et al. (1996) suggested that GML may play a role in the apoptotic pathway or cell cycle regulation induced by p53 after DNA damage.Kimura et al. (1997) found that the GML gene consists of 4 exons spanning 12 kb, with a p53-binding site 19 kb upstream of the first exon.

Reference

"Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity."
Oncogene 13:1965-1970(1996) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53."
Genomics 41:477-480(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]