Ankyrin Repeat Domain Protein 1 (ANKRD1)

CARP; ALRP; C-193; CVARP; MCARP; Ankyrin Repeat Domain 1(Cardiac Muscle); Cardiac ankyrin repeat protein; Cytokine-inducible gene C-193; Cytokine-inducible nuclear protein

SPN	P858
HGNC	15819
MGI	1097717
PubMed	19608030
RGD	61989
UniProt	Q15327
Wiki	ANKRD1

Expression of MARPs is induced in response to physiologic stress, injury, and hypertrophy.The deduced 319-amino acid protein has a calculated molecular mass of 36 kD. ANKRD1 contains a nuclear localization signal, 4 tandem ankyrin-like repeats, multiple phosphorylation sites, and a PEST-rich region, which is typically found in rapidly degraded proteins. The 3-prime UTR of ANKRD1 has numerous AT-rich mRNA decay elements. Northern blot analysis of multiple human cell lines detected ANKRD1 expression in microvascular and large vessel endothelial cell lines. Immunofluorescence of transfected COS cells and immunoprecipitation of nuclear and cytoplasmic extracts of COS cells showed that ANKRD1 was abundantly expressed in nucleus.

Reference

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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules."
J. Mol. Biol. 333:951-964(2003) [PubMed] [Europe PMC] [Abstract]

"Transcriptional deregulation and a missense mutation define ANKRD1 as a candidate gene for total anomalous pulmonary venous return."
Hum. Mutat. 29:468-474(2008) [PubMed] [Europe PMC] [Abstract]