Voltage Dependent Anion Channel Protein 1 (VDAC1)

PORIN-31-HL; Porin 31HM; Plasmalemmal porin; Outer mitochondrial membrane protein porin 1; Voltage-dependent anion-selective channel protein 1

SPN	P845
HGNC	12669
MGI	106919
PubMed	18362892
RGD	621575
UniProt	P21796
Wiki	VDAC1

The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane is a small, abundant outer membrane pore-forming protein found in the outer membranes of all eukaryotic mitochondria. The VDAC protein is thought to form the major pathway for movement of adenine nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and glycerol kinase.

Mitochondria expressing VDAC1 were capable of specifically binding hexokinase, whereas mitochondria expressing VDAC2 only bound hexokinase at background levels. Each human cDNA was expressed in essentially all human cell lines and tissues examined.

Reference

"Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."
J. Biol. Chem. 268:1835-1841(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning of human VDAC cDNA."
Biophys. J. 59:216A-216A(1991)

"Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
Mamm. Genome 10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human porin isoform 1 (HVDAC1) gene by amplification on the whole human genome: a tool for porin deficiency analysis."
Biochem. Biophys. Res. Commun. 270:787-792(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL)."
Biol. Chem. Hoppe-Seyler 370:1265-1278(1989) [PubMed] [Europe PMC] [Abstract]

"Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical."
Biol. Chem. Hoppe-Seyler 372:455-463(1991) [PubMed] [Europe PMC] [Abstract]