UDP Glucuronate Decarboxylase 1 (UXS1)
UGD; SDR6E1; Short Chain Dehydrogenase/reductase Family 6E,Member 12; UDP-glucuronic acid decarboxylase 1
UDP-glucuronate decarboxylase (UGD; EC 4.1.1.35) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans.
The topology of the deduced 420-amino acid protein was consistent with a type II transmembrane protein. Northern blot analysis of rat tissues detected a single UGD transcript with highest levels in heart, brain, and testes. Substantial levels were also detected in kidney, liver and lung, and lower levels in spleen and skeletal muscle. Western blot analysis demonstrated highest levels of the protein in kidney, liver, and brain, with negligible staining in heart, spleen, skeletal muscle, lung, and testes. Subcellular studies and histochemistry localized the protein to the perinuclear Golgi.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Hu01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Hu01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Hu01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Hu01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Hu01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Mu01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Mu01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Mu01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Mu01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Mu01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Ra01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Ra01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Ra01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Ra01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Ra01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Ca01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Ca01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Ca01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Ca01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Ca01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Po01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Po01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Po01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Po01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Po01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Bo01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Bo01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Bo01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Bo01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Bo01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Rb01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Rb01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Rb01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Rb01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Rb01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP840Mo01 | Recombinant UDP Glucuronate Decarboxylase 1 (UXS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP840Mo01 | Monoclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IP. |
| PAP840Mo01 | Polyclonal Antibody to UDP Glucuronate Decarboxylase 1 (UXS1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP840Mo01 | CLIA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | CLIA assay for Antigen Detection |
| ELP840Mo01 | ELISA Kit for UDP Glucuronate Decarboxylase 1 (UXS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development."
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Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human UDP-glucoronic acid decarboxylase."
Submitted (OCT-2005) to the PDB data bank