Interferon Alpha 21 (IFNa21)

LeIF F; Interferon alpha-F

SPN	P786
HGNC	5424
PubMed	21307941
UniProt	P01568
Wiki	IFNA21

The IFNA21 gene was positioned in the cluster of interferon genes on 9p22 by deletion mapping. Interferons (IFNs) are proteins made and released by lymphocytes in response to the presence of pathogens—such as viruses, bacteria, or parasites—or tumor cells. IFNs belong to the large class of glycoproteins known as cytokines. Although they are named after their ability to "interfere" with viral replication within host cells, IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they increase the ability of uninfected host cells to resist new infection by virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Hu01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Hu01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Hu01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Hu01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Hu01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Mu01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Mu01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Mu01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Mu01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Mu01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Ra01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Ra01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Ra01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Ra01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Ra01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Ca01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Ca01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Ca01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Ca01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Ca01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Po01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Po01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Po01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Po01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Po01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Bo01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Bo01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Bo01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Bo01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Bo01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Rb01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Rb01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Rb01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Rb01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Rb01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP786Mo01	Recombinant Interferon Alpha 21 (IFNa21)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP786Mo01	Monoclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IP.
Antibodies	PAP786Mo01	Polyclonal Antibody to Interferon Alpha 21 (IFNa21)	WB; IHC; ICC; IF.
Assay Kits	CLP786Mo01	CLIA Kit for Interferon Alpha 21 (IFNa21)	CLIA assay for Antigen Detection
Assay Kits	ELP786Mo01	ELISA Kit for Interferon Alpha 21 (IFNa21)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The structure of eight distinct cloned human leukocyte interferon cDNAs."
Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]

"A new type of leukocytic interferon."
Dokl. Biochem. 269:91-95(1983)

"Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes."
J. Interferon Res. 4:609-617(1984) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Anomalous behavior of human leukocyte interferon subtypes on polyacrylamide gel electrophoresis in the presence of dodecyl sulfate."
FEBS Lett. 211:78-82(1987) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]

"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population."
J. Interferon Cytokine Res. 16:853-859(1996) [PubMed] [Europe PMC] [Abstract]