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TTK Protein Kinase (TTK)

MPS1; MPS1L1; CT96; PYT; Cancer/Testis Antigen 96; Phosphotyrosine picked threonine-protein kinase; Dual specificity protein kinase TTK

Protein kinases are generally divided into 2 broad classes based on their ability to phosphorylate either tyrosine (tyr) or serine/threonine (ser/thr) residues. However, several protein kinases have dual specificity and are able to phosphorylate all 3 amino acids.TTK encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Hu01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Hu01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Hu01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Hu01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Hu01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Mu01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Mu01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Mu01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Mu01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Mu01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Ra01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Ra01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Ra01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Ra01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Ra01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Ca01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Ca01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Ca01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Ca01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Ca01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Po01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Po01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Po01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Po01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Po01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Bo01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Bo01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Bo01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Bo01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Bo01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Rb01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Rb01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Rb01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Rb01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Rb01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP758Mo01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP758Mo01 Monoclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
PAP758Mo01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IF.
Assay Kits CLP758Mo01 CLIA Kit for TTK Protein Kinase (TTK) CLIA assay for Antigen Detection
ELP758Mo01 ELISA Kit for TTK Protein Kinase (TTK) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine."
Oncogene 8:351-359(1993) [PubMed] [Europe PMC] [Abstract]

"Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members."
Methods Enzymol. 200:38-62(1991) [PubMed] [Europe PMC] [Abstract]

"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]

"Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment."
Cell 132:233-246(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator."
J. Cell Biol. 184:647-657(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
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"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125."
J. Biol. Chem. 283:21495-21500(2008) [PubMed] [Europe PMC] [Abstract]

"Structural and mechanistic insights into Mps1 kinase activation."
J. Cell. Mol. Med. 13:1679-1694(2009) [PubMed] [Europe PMC] [Abstract]