Talin 2 (TLN2)

ILWEQ

SPN	P728
HGNC	15447
MGI	1917799
PubMed	11527381
RGD	1565416
UniProt	Q9Y4G6
Wiki	TLN2

TLN2 encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.

The deduced 2,532-amino acid protein contains a FERM domain. In TLN1, the FERM domain binds the cytodomains of beta-1 and beta-3 integrins, as well as to F-actin and other proteins. TLN2 shares 74% identity with TLN1, and the N- and C-terminal regions of TLN2 are highly conserved across species.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Hu01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Hu01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Hu01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Hu01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Hu01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Mu01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Mu01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Mu01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Mu01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Mu01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Ra01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Ra01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Ra01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Ra01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Ra01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Ca01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Ca01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Ca01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Ca01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Ca01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Po01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Po01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Po01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Po01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Po01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Bo01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Bo01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Bo01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Bo01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Bo01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Rb01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Rb01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Rb01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Rb01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Rb01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP728Mo01	Recombinant Talin 2 (TLN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP728Mo01	Monoclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IP.
Antibodies	PAP728Mo01	Polyclonal Antibody to Talin 2 (TLN2)	WB; IHC; ICC; IF.
Assay Kits	CLP728Mo01	CLIA Kit for Talin 2 (TLN2)	CLIA assay for Antigen Detection
Assay Kits	ELP728Mo01	ELISA Kit for Talin 2 (TLN2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin."
Nature 420:85-89(2002) [PubMed] [Europe PMC] [Abstract]

"Analysis of the mammalian talin2 gene TLN2."
Biochem. Biophys. Res. Commun. 286:880-885(2001) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

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Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]