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Synaptotagmin Like Protein 2 (SYTL2)

CHR11SYT; SGA72M; SLP2; Exophilin-4; Breast Cancer-Associated Antigen SGA-72M

SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.
The deduced 913-amino acid protein shares significant similarity with electric ray synaptotagmin . RT-PCR detected SYTL2 in all adult and fetal tissues examined, with highest expression in kidney and brain and in most specific brain regions examined. Very low expression was found in pancreas and testis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Hu01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Hu01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Hu01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Hu01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Hu01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Mu01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Mu01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Mu01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Mu01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Mu01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Ra01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Ra01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Ra01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Ra01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Ra01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Ca01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Ca01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Ca01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Ca01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Ca01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Po01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Po01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Po01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Po01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Po01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Bo01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Bo01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Bo01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Bo01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Bo01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Rb01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Rb01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Rb01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Rb01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Rb01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP674Mo01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP674Mo01 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAP674Mo01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IF.
Assay Kits CLP674Mo01 CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA assay for Antigen Detection
ELP674Mo01 ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates in cytotoxic granule secretion."
Blood 112:5052-5062(2008) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain."
Mol. Biol. Cell 18:688-696(2007) [PubMed] [Europe PMC] [Abstract]

"Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse."
Traffic 9:446-457(2008) [PubMed] [Europe PMC] [Abstract]

"Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a."
Structure 16:1468-1477(2008) [PubMed] [Europe PMC] [Abstract]