Sulfite Oxidase (SUOX)

SPN	P646
HGNC	11460
MGI	2446117
PubMed	23665285
RGD	619994
UniProt	P51687
Wiki	SUOX

Sulfite oxidase (EC 1.8.3.1) is an enzyme in the mitochondria of all eukaryotes. It oxidizes sulfite to sulfate and, via cytochrome c, transfers the electrons produced to the electron transport chain, allowing generation of ATP in oxidative phosphorylation. This is the last step in the metabolism of sulfur-containing compounds and the sulfate is excreted.

Sulfite oxidase is a metallo-enzyme that utilizes a molybdopterin cofactor and a heme group. It is one of the cytochromes b₅ and belongs to the enzyme super-family of oxotransferases that also includes DMSO reductase, xanthine oxidase, and nitrite reductase.In mammals, the expression levels of sulfite oxidase is high in the liver, kidney, and heart, and very low in spleen, brain, skeletal muscle, and blood.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Hu01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Hu01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Hu01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Hu01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Hu01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Mu01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Mu01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Mu01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Mu01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Mu01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Ra01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Ra01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Ra01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Ra01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Ra01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Ca01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Ca01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Ca01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Ca01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Ca01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Po01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Po01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Po01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Po01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Po01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Bo01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Bo01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Bo01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Bo01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Bo01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Rb01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Rb01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Rb01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Rb01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Rb01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP646Mo01	Recombinant Sulfite Oxidase (SUOX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP646Mo01	Monoclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IP.
Antibodies	PAP646Mo01	Polyclonal Antibody to Sulfite Oxidase (SUOX)	WB; IHC; ICC; IF.
Assay Kits	CLP646Mo01	CLIA Kit for Sulfite Oxidase (SUOX)	CLIA assay for Antigen Detection
Assay Kits	ELP646Mo01	ELISA Kit for Sulfite Oxidase (SUOX)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of human liver sulfite oxidase."
Biochim. Biophys. Acta 1262:147-149(1995) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain."
Acta Crystallogr. D 59:1183-1191(2003) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase."
Cell 91:973-983(1997) [PubMed] [Europe PMC] [Abstract]

"Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme."
Proc. Natl. Acad. Sci. U.S.A. 95:6394-6398(1998) [PubMed] [Europe PMC] [Abstract]

"Isolated sulfite oxidase deficiency: review of two cases in one family."
Ophthalmology 106:1957-1961(1999) [PubMed] [Europe PMC] [Abstract]

"Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients."
Hum. Mutat. 20:74-74(2002) [PubMed] [Europe PMC] [Abstract]

"A novel mutation in neonatal isolated sulphite oxidase deficiency."
Neuropediatrics 33:174-179(2002) [PubMed] [Europe PMC] [Abstract]