Serine/Threonine Kinase 3 (STK3)

KRS1; MST2; Mammalian STE20-like protein kinase 2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1

SPN	P624
HGNC	11406
MGI	1928487
PubMed	8816758
RGD	68412
UniProt	Q13188
Wiki	MST2

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand. Sequence analysis indicated that, like STK4, the deduced 491-amino acid STK3 protein contains an N-terminal catalytic domain characteristic of STKs. This N-terminal domain is nearly identical to that of STK4, but the C terminus shares only 60% amino acid identity.

Reference

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Gene 167:303-306(1995) [PubMed] [Europe PMC] [Abstract]

"Newly identified stress-responsive protein kinases, Krs-1 and Krs-2."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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, Submitted (JUL-2007) to UniProtKB

"Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans."
Cell Growth Differ. 4:821-830(1993) [PubMed] [Europe PMC] [Abstract]

"MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation."
J. Biol. Chem. 276:19276-19285(2001) [PubMed] [Europe PMC] [Abstract]

"Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1."
Science 306:2267-2270(2004) [PubMed] [Europe PMC] [Abstract]

"The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1."
Oncogene 24:2076-2086(2005) [PubMed] [Europe PMC] [Abstract]

"Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis."
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"Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation."
FEBS J. 273:4264-4276(2006) [PubMed] [Europe PMC] [Abstract]

"MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation."
Curr. Biol. 18:311-321(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1."
Oncogene 27:4281-4292(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
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"Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling."
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"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"RASSF2 associates with and stabilizes the proapoptotic kinase MST2."
Oncogene 28:2988-2998(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt."
Cancer Res. 70:1195-1203(2010) [PubMed] [Europe PMC] [Abstract]

"Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation."
J. Biol. Chem. 285:15076-15087(2010) [PubMed] [Europe PMC] [Abstract]

"Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction."
Nat. Cell Biol. 12:1166-1176(2010) [PubMed] [Europe PMC] [Abstract]

"Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway."
PLoS ONE 5:E9616-E9616(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2."
J. Biol. Chem. 286:6253-6261(2011) [PubMed] [Europe PMC] [Abstract]

"Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand."
J. Mol. Med. 89:181-191(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]