Retbindin (RTBDN)

SPN	P539
HGNC	30310
MGI	2443686
PubMed	12107411
RGD	1308534
UniProt	Q9BSG5

Using expressed sequence tag (EST) analysis of unamplified cDNA libraries generated from human retina, Wistow et al. (2002) identified an abundant novel open reading frame that encoded a 229-residue protein with a predicted molecular mass of 24.6 kD.

The corresponding gene, which they named retbindin (RTBDN), shows modest sequence homology to riboflavin-binding proteins of egg-laying vertebrates, and more distant similarity to mammalian folate receptors. Analysis of the 5-prime ends of multiple RTBDN clones identified splice variants that suggested the presence of multiple promoters. Northern blot analysis of rhesus monkey tissues showed retina-specific expression of a 1.2-kb RTBDN transcript.

Reference

"Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts."
Mol. Vis. 8:196-204(2002) [PubMed] [Europe PMC] [Abstract]

"Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]