Receptor Activity Modifying Protein 2 (RAMP2)

Calcitonin-receptor-like receptor activity-modifying protein 2; Receptor(G Protein-Coupled)Activity Modifying Protein 2; Receptor(Calcitonin)Activity Modifying Protein 2

SPN	P480
HGNC	9844
MGI	1859650
PubMed	9620797
RGD	61872
UniProt	O60895
Wiki	RAMP2

RAMP2 encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N-terminus and a cytoplasmic C-terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

Reference

"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor."
Nature 393:333-339(1998) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the extracellular domain of human RAMP2."
Submitted (DEC-2010) to the PDB data bank

"Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding."
Protein Sci. 21:199-210(2012) [PubMed] [Europe PMC] [Abstract]