Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP)

PBF; C21orf1; C21orf3; Pituitary tumor-transforming gene protein-binding factor

SPN	P462
HGNC	13524
MGI	2652132
PubMed	21844185
RGD	1305983
UniProt	P53801
Wiki	PTTG1IP

PTTG1IP, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1.

The predicted 180-amino acid C21ORF3 protein has features of a type Ia integral membrane protein and contains the tetrapeptide YXRF, a motif observed in proteins internalized via coated pit-mediated endocytosis. Northern blot analysis detected a 2.69-kb C21ORF3 mRNA in all tissues examined.

Reference

"Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3."
Genomics 49:133-136(1998) [PubMed] [Europe PMC] [Abstract]

"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product."
J. Biol. Chem. 275:19422-19427(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of novel genes of the bone-specific transcription factor Runx2."
J. Bone Miner. Res. 19:959-972(2004) [PubMed] [Europe PMC] [Abstract]